Having spent the summer engaging common criminals with his new-found powers, not so typical 16-year-old Peter Parker must conceal his secret identity and battle super-villains in the real world as he enters his junior year of high school.
Survival of the Fittest
While being pursued by the Enforcers, Spider-Man has to protect Norman Osborn from the vengeful supervillain Vulture.
Interactions
When a lab accident transforms Max Dillon into supervillain Electro, he demands that Dr. Martha Connors find a cure as Spider-Man works to stop him.
Natural Selection
When. Dr. Curt Connors' attempt to regenerate a new arm accidentally transforms him into the Lizard, Peter, Martha, Eddie and Gwen search for a cure.
Market Forces
Following orders from Kingpin, Hammerhead hires Montana to steal a high-tech suit and, as the Shocker, destroy Spider-Man.
Competition
As Peter Parker and Harry Osborn try out for the football team, Spider-Man must face convict Flint Marko, newly transformed into the Sandman in order to destroy Spider-Man.
The Invisible Hand
As Otto creates the Rhino as a new distraction for Spider-Man, Peter takes Aunt May's advice and asks Mary Jane Watson to the high school prom.
Catalysts
Peter and Mary Jane are a hit at the Fall Formal. Meanwhile, the Green Goblin's attack on Fisk Industries requires Spider-Man's intervention.
Reaction
When the Green Goblin fuses Otto's robotic arms to his body, the newly created Doctor Octopus must find a new power source as Spider-Man pursues him.
The Uncertainty Principle
Spider-Man faces off against the Green Goblin and Tombstone. Elsewhere, Col. John Jameson attempts to land a damaged space shuttle.
Persona
Disguised as Spider-Man, the Chameleon embarks on a crime spree that can only be stopped by Spidey and the Black Cat -- together.
Group Therapy
When the Sinister Six escape from prison with plans to take down Spider-Man, they nearly succeed. But Peter wakes up with no memory of the battle.
Intervention
As he struggles with the alien symbiote, Spider-Man's origins are revealed.
Nature vs. Nurture
Venom -- the merged entity consisting of Eddie Brock and the symbiote -- attacks Spider-Man through the people he loves most.
